Symbol
Name
ID

Ank1
ankyrin 1, erythroid
MGI:88024

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased mean corpuscular hemoglobin concentration	Reticulocytosis	Anemia	Hemolytic anemia	Spontaneous hemolytic crises	Spherocytosis	Increased red cell osmotic fragility	Hypofibrinogenemia	Hypercoagulability	Extramedullary hematopoiesis	Splenomegaly
Disease(s) Associated with ANK1	Increased mean corpuscular hemoglobin concentration	Reticulocytosis	Anemia	Hemolytic anemia	Spontaneous hemolytic crises	Spherocytosis	Increased red cell osmotic fragility	Hypofibrinogenemia	Hypercoagulability	Extramedullary hematopoiesis	Splenomegaly
hereditary spherocytosis
hereditary spherocytosis type 1

Mouse Phenotypes

abnormal thymus development

enlarged spleen

increased spleen weight

abnormal common myeloid progenitor cell morphology

decreased common myeloid progenitor cell number

abnormal erythropoiesis

abnormal myelopoiesis

extramedullary hematopoiesis

anemia

hemolytic anemia

hypochromic anemia

microcytic anemia

increased erythroid progenitor cell number

erythroblastosis

abnormal erythrocyte morphology

decreased erythrocyte cell number

low mean erythrocyte cell number

increased erythrocyte cell number

polycythemia

decreased hematocrit

decreased cellular hemoglobin content

increased hemoglobin concentration distribution width

decreased hemoglobin content

decreased mean corpuscular hemoglobin

decreased mean corpuscular hemoglobin concentration

decreased mean corpuscular volume

increased nucleated erythrocyte cell number

anisocytosis

acanthocytosis

anisopoikilocytosis

hyperchromasia

increased erythrocyte protoporphyrin level

microcytosis

poikilocytosis

schistocytosis

polychromatophilia

spherocytosis

stomatocytosis

increased neutrophil cell number

thrombocytosis

abnormal leukocyte cell number

increased lymphocyte cell number

increased leukocyte cell number

reticulocytosis

abnormal spleen morphology

decreased spleen iron level

increased spleen iron level

abnormal erythrocyte physiology

increased erythrocyte clearance

hemolysis

increased erythrocyte osmotic fragility

Availability

Mouse Genotype

Ank1^ity16/Ank1^ity16

Ank1^M1Btlr/Ank1^M1Btlr

Ank1^M1Wlst/Ank1^M1Wlst

Ank1^MRI23420/Ank1^MRI23420

Ank1^nb/Ank1^nb

Ank1^Rbc2/Ank1^Rbc2

Ank1^ity16/Ank1⁺

Ank1^M1Btlr/Ank1⁺

Ank1^M1Wlst/Ank1⁺

Ank1^MRI23420/Ank1⁺

Ank1^nb/Ank1⁺

Ank1^Rbc2/Ank1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23